WTA No 1 Serena Williams, 33, needed two hours and one minute to win 6-3 6-7 (2-7) 6-2 at Roland Garros.
Lucie Safarova, who played her first Grand Slam final, led by a break in the decider but Serena Williams won the last six games.
Serena Williams becomes the third player – male or female – to win 20 major singles titles.
Only Germany’s Steffi Graf on 22 has won more since the open era began in 1968, with Australia’s Margaret Court collecting 24 between 1960 and 1973.
Victory at Wimbledon in July would see Serena Williams hold all four major titles at once, having managed the feat already in 2003.
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