More than 600 flights were cancelled and thousands delayed by a winter storm which brought snow, sleet and rain.
As much as 12in of snow was due in the heavily populated north-east, forcing people to change travel plans.
More than 46 million Americans are expected to be on the move on November 26, mostly by car.
That would make it the busiest Thanksgiving travel since 2007, according to the American Automobile Association (AAA), with most people travelling by cars.
Snow has already begun falling in the East but New York City could see as much as four inches of snow, while between six and 12 inches is expected to fall further north.
New York Governor Andrew Cuomo activated the state’s Emergency Operations Center and had 1,800 snowplough operators standing by to clear roads between New York City and Albany.
Airlines were suggesting travelers switch to earlier flights, with some dropping change fees.
Snow is also expected in Philadelphia, Baltimore and Washington DC.
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