The solar-powered plane will be taken on a round-the-world journey in 2015.
The Solar Impulse 2 vehicle lifted off from Payerne airfield in Switzerland at just after 03:35 GMT, returning two hours later.
It is a larger, upgraded version of the aircraft that flew across America last year with adventurers Bertrand Piccard and Andre Borschberg at the controls.
For this maiden flight, test pilot Markus Scherdel was in the cockpit.
He climbed to just under 6,000ft, conducting a number of maneuvers to prove the handling of the aircraft.
Markus Scherdel reported some early vibrations, but overall the mission outcome appeared very positive.
“The initial results are in line with calculations and simulations,” read a later statement from the team.
Further flights will be conducted in the coming months in order for the experimental machine to attain certification.
The carbon-fiber aircraft has a huge wingspan, which at 72m is wider than a Boeing 747 jet. And yet, the vehicle weighs only 2.3 tonnes.
The tops of the wings are covered by 17,000 solar cells, which drive four brushless electric motors at speeds of up to 90mph.
During the day, the solar cells will recharge lithium batteries, which can then be used to keep the plane’s propellers turning through the night.
The first Solar Impulse plane set a number of world records, including the longest manned solar-powered flight at 26 hours, the first inter-continental flight in a solar-powered plane, and the greatest distance covered on a piloted solar-powered flight. (Autonomous solar-powered drones can stay aloft for weeks).
That last record was set during Bertrand Piccard’s and Andre Borschberg’s epic TransAmerica journey in May, June and July last year.
But as challenging as that effort was, it will be dwarfed by the difficulty and complexity of completing a global flight.
This is because it will have to include passage across the Atlantic and Pacific Oceans. The latter could take all of five days and nights to complete.
Only one pilot can fit in the cockpit. It has a reclining seat to make room for exercising and to permit Bertrand Piccard and Andre Borschberg, whoever is at the controls, to take short catnaps.
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