The cause of death was announced by the office of the medical examiner after L’Wren Scott’s body was discovered in her flat by her assistant on Monday.
Police earlier said there was no sign of foul play and no note was found.
L’Wren Scott’s long-term partner, Mick Jagger, postponed forthcoming Rolling Stones tour dates in Australia and New Zealand after her death was announced.
Mick Jagger earlier said he failed “to understand how my lover and best friend could end her life in this tragic way”.
He said they had spent “many wonderful years together”.
Tributes have poured in for L’Wren Scott, 49, with fans including supermodel Naomi Campbell, Vogue editor Anna Wintour and Madonna eulogizing the fashion designer.
L’Wren Scott was found in her Manhattan apartment by her assistant at 10:00 a.m. local time on Monday.
The fashion designer had sent her assistant a text message 90 minutes earlier asking her to come to the apartment, without specifying the reason why, the Associated Press news agency reported.
It has since emerged that the fashion label founded by L’Wren Scott had been heavily in debt.
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