The sequel, which has now made $1.14 billion worldwide, overtook 2011’s Transformers: Dark of the Moon to claim fifth place in the chart.
Avatar and Titanic remain the all-time box-office champions, having both grossed more than $2bn worldwide.
Avengers Assemble and the final Harry Potter are ranked third and fourth.
Iron Man 3 is the fourth film to feature Robert Downey Jr.’s metal-clad crime-fighter.
The third was 2012’s Avengers Assemble, known in the US as The Avengers, whose current worldwide box office tally stands at $1.51 billion.
Iron Man 3 continues to perform strongly, although it has some way to go before its takings exceed the $1.34 billion that Harry Potter and the Deathly Hallows Part 2 conjured up in 2011.
Once figures have been adjusted for inflation, however, neither title features in the US domestic all-time top 100, which is headed up by Gone With the Wind.
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