The second film, New Moon, took $142.8m in its first three days in 2009.
Breaking Dawn – Part 2, which is the fifth Twilight film, now ranks eighth in the list of US domestic debuts.
It also took just under $200 million internationally between Thursday and Sunday in 61 countries.
Breaking Dawn – Part 2 joins New Moon, which sits in seventh place, and the fourth film – Breaking Dawn – Part 1 – at number nine.
Batman is the only other franchise with more than one top-10 opening, with The Dark Knight Rises and The Dark Knight at number three and number four respectively.
Paul Dergarabedian, an analyst for box officer tracker Hollywood.com, described Twilight as “one of the most consistently performing franchises of all time”.
“I thought that for the final installment, it might eclipse the franchise record, but to look at $141.3 million and say that’s a disappointment, that’s kind of crazy,” he said.
The Twilight films, based on Stephanie Meyer’s best-selling novels, star Robert Pattinson and Kristen Stewart.
Breaking Dawn – Part 2 knocked Bond film Skyfall off the top of the chart, which fell into second place with $41.5 million.
Steven Spielberg’s Lincoln was released nationwide following a limited release last week, taking $21 million to secure third position.
Disney animation Wreck-It Ralph and Denzel Washington drama Flight rounded out the top five.
US box office top five:
1. The Twilight Saga: Breaking Dawn – Part 2 $141.3 million
2. Skyfall $41.5 million
3. Lincoln $21 million
4. Wreck-It Ralph $18.3 million
5. Flight $8.6 million
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