The suspected car bomb exploded close to a police station in Gaziantep, Turkey’s Dogan news agency reported.
Police officers were reported to be among the casualties and media showed a bus and other vehicles on fire.
No group has so far said it carried out the attack.
However, rebels from the outlawed Kurdistan Workers’ Party (PKK) are active in south-eastern Turkey, which has a Kurdish majority.
Gaziantep’s governor Erdal Ata said the explosion had been caused by a remote-controlled car bomb, the Dogan agency said.
Earlier on Monday, two Turkish soldiers were killed and another wounded in a mine blast in south-eastern Hakkari province. Turkish officials blamed the attack on the PKK.
Clashes between the PKK – which seeks autonomy for the Kurds – and Turkey’s armed forces have increased in south-eastern Turkey over the past year.
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