The man, believed to be aged 30, was injured just before 19:45 BST at the junction of Ruckholt Road and East Cross Road, Hackney.
Police and an air ambulance attended but the man was pronounced dead at the scene about half an hour later.
The crash involved a media bus.
No arrests have been made in connection with the incident.
The crash happened close to the Olympic hockey centre, velodrome and Paralympic tennis arena.
The victim has not yet been identified, but an International Olympic Committee official said the dead man was not an athlete.
Following the collision no buses were allowed to arrive or depart from the Media Transport Mall’s multi-story car park.
The Olympic Park internal shuttle remains operational.
The incident is being investigated by the Met’s Traffic Investigation Unit.
LOCOG has said it will provide updates as they become available.
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