It saw the cartoon family exiled to a community of outsiders where they met Wikileaks founder Julian Assange.
Fox TV said Julian Assange recorded his lines from the UK, where he is fighting extradition to Sweden over alleged sex offences – charges he denies.
The animated comedy is in its 23rd season, making it the longest-running prime-time scripted programme on TV.
The Simpsons show is contracted to run for another two seasons.
They subsequently find a welcome in “The Outlands”, where Julian Assange is their neighbor.
Previous guest voices on the programme include former Prime Minister Tony Blair, graffiti artist Banksy and novelist Thomas Pynchon.
Once the show’s 25th season has been completed, the number of episodes made will stand at 559.
Creator Matt Groening said the writers still had stories to tell, mostly involving “characters we’ve never dealt with”.
“We have a character we call Squeaky-Voiced Teen,” Matt Groening told the Los Angeles Times.
“I’d like to know a little bit more about that guy.”
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